Isoniazid Preventive Therapy Revisited

Isoniazid preventive therapy in correctional facilities: a systematic review.

Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide and the main cause of death in correctional facilities in middle- and low-income countries. Due to the closed environment and the concentration of individuals with TB-related risk factors, effective measures are required to control TB in such settings. Isoniazid preventive therapy (IPT) represents an effective and cost...

Isoniazid Preventive Therapy and Risk for Resistant Tuberculosis

In the context of tuberculosis (TB) resurgence, isoniazid preventive therapy (IPT) is increasingly promoted, but concerns about the risk for development of isoniazid-resistant tuberculosis may hinder its widespread implementation. We conducted a systematic review of data published since 1951 to assess the effect of primary IPT on the risk for isoniazid-resistant TB. Different definitions of iso...

Eligibility for Isoniazid Preventive Therapy in South African Gold Mines

SETTING The "Thibela TB" cluster randomised trial of community-wide isoniazid preventive therapy (IPT) to reduce tuberculosis incidence in the South African gold mines. OBJECTIVES To determine the proportion of participants eligible for IPT and the reasons and risk factors for ineligibility, to inform the scale-up of IPT. DESIGN Cross-sectional survey of participants in intervention cluster...

A trial of mass isoniazid preventive therapy for tuberculosis control.

BACKGROUND Tuberculosis is epidemic among workers in South African gold mines. We evaluated an intervention to interrupt tuberculosis transmission by means of mass screening that was linked to treatment for active disease or latent infection. METHODS In a cluster-randomized study, we designated 15 clusters with 78,744 miners as either intervention clusters (40,981 miners in 8 clusters) or con...

Community Health Workers Can Strengthen Isoniazid Preventive Therapy Implementation in Rural KwaZulu-Natal, South Africa